Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | UGCG | Q16739 | 5/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695783 | 0.89 | GHSR (0.53) | GHSRP2RX7UGCGCCKBRCYP3A4 | |
| SCHEMBL6693779 | 0.89 | GHSR (0.53) | GHSRP2RX7UGCGCCKBRCYP3A4 | |
| SCHEMBL6689707 | 0.89 | GHSR (0.53) | GHSRP2RX7UGCGCCKBRCYP3A4 | |
| SCHEMBL5229183 | 0.87 | GHSR (0.45) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL5229912 | 0.86 | GHSR (0.45) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL6705735 | 0.84 | GHSR (0.42) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL6690540 | 0.84 | GHSR (0.45) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL6695743 | 0.84 | GHSR (0.42) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL6691512 | 0.84 | GHSR (0.42) | GHSRP2RX7PPARAUGCGCCKBR | |
| SCHEMBL6689702 | 0.83 | GHSR (0.40) | GHSRUGCGCCKBRTACR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1002802-B1 | Dipeptide derivatives as growth hormone secretagogues | PFIZER PROD INC (US) | 2004-12-08 | — | — | EP | disclosed |
| US-6194578-B1 | GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1002802-A1 | Dipeptide derivatives as growth hormone secretagogues | Pfizer Products Inc. (US) | 2000-05-24 | — | — | EP | disclosed |