Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750567 | 0.85 | HDAC2 (0.53) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL1750441 | 0.80 | HDAC2 (0.51) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL12235510 | 0.79 | L3MBTL1 (0.50) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL13739258 | 0.78 | HDAC2 (0.64) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL26696780 | 0.76 | HDAC2 (0.47) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL20817404 | 0.76 | CTSK (0.49) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL29273743 | 0.76 | EPHX1 (0.57) | HDAC2HDAC8HDAC6HDAC4CTSK | |
| SCHEMBL27498988 | 0.76 | HDAC4 (0.45) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL23975137 | 0.75 | CTSK (0.48) | HDAC2HDAC8HDAC6HDAC4HDAC1 | |
| SCHEMBL14880140 | 0.74 | HDAC2 (1.00) | HDAC2HDAC8HDAC6HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |