Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8231920 | 0.85 | DPP4 (0.45) | DPP4DPP7DPP8DPP9RIPK1 | |
| SCHEMBL8310385 | 0.81 | DPP4 (0.44) | DPP4DPP7DPP8DPP9RIPK1 | |
| SCHEMBL726821 | 0.81 | SLC22A6 (0.43) | DPP4DPP7DPP8DPP9SLC22A6 | |
| SCHEMBL29364465 | 0.81 | SLC22A6 (0.43) | DPP4DPP7DPP8DPP9SLC22A6 | |
| SCHEMBL726822 | 0.81 | SLC22A6 (0.43) | DPP4DPP7DPP8DPP9SLC22A6 | |
| SCHEMBL5813062 | 0.79 | DPP4 (0.46) | DPP4DPP7DPP8DPP9RIPK1 | |
| SCHEMBL28074185 | 0.75 | MME (0.50) | SLC22A6 | |
| SCHEMBL6690036 | 0.75 | CYP3A4 (0.41) | DPP4DPP7DPP9 | |
| SCHEMBL3973347 | 0.75 | DPP4 (0.47) | DPP4DPP7DPP8DPP9RIPK1 | |
| SCHEMBL188142 | 0.75 | USP2 (0.54) | DPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087650-A2 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BETA-AMINO ACID AMIDE DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK & CO. INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087650-A2 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BETA-AMINO ACID AMIDE DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK & CO. INC. (US) | 2004-10-14 | — | — | WO | disclosed |