Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923413 | 0.98 | ALKBH2 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL3149078 | 0.76 | ALKBH2 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL20658802 | 0.76 | ALKBH2 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL15671484 | 0.76 | EGLN1 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL5668701 | 0.76 | ALKBH2 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL2159890 | 0.76 | ALKBH2 (0.57) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL1198582 | 0.75 | PRKCI (0.42) | ALKBH2EGLN1DRD2DRD4DRD3 | |
| SCHEMBL12402325 | 0.74 | PRKCI (0.43) | ALKBH2EGLN1PRKCIMEN1KMT2A | |
| SCHEMBL12075257 | 0.74 | ALKBH2 (0.54) | ALKBH2EGLN1GRM4DRD2DRD4 | |
| SCHEMBL5667864 | 0.74 | GRM5 (0.52) | ALKBH2EGLN1GRM4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |