SCHEMBL6694201

SCHEMBL6694201

COC1=CC(=O)N2CCN(C(=O)C(COCc3ccccc3)NC(=O)C(C)(C)N)CC12Cc1ccccn1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 13/20 0.53
UGCG Q16739 7/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6694204 1.00 GHSR (0.53) GHSRUGCG
SCHEMBL6695238 1.00 GHSR (0.53) GHSRUGCG
SCHEMBL7899507 0.89 GHSR (0.42) GHSRUGCG
SCHEMBL7899504 0.89 GHSR (0.42) GHSRUGCG
SCHEMBL6691541 0.87 GHSR (0.54) GHSRUGCG
SCHEMBL6691543 0.87 GHSR (0.54) GHSRUGCG
SCHEMBL5228136 0.86 GHSR (0.58) GHSRUGCG
SCHEMBL5225968 0.86 GHSR (0.58) GHSRUGCG
SCHEMBL6691119 0.85 GHSR (0.52) GHSRUGCG
SCHEMBL6691115 0.85 GHSR (0.52) GHSRUGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1002802-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER PROD INC (US) 2004-12-08 EP claimed
US-6194578-B1 GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS PFIZER INC. 2001-02-27 US claimed
EP-1002802-A1 Dipeptide derivatives as growth hormone secretagogues Pfizer Products Inc. (US) 2000-05-24 EP claimed
EP-1002802-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER PROD INC (US) 2004-12-08 EP disclosed
US-6194578-B1 GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS PFIZER INC. 2001-02-27 US disclosed
EP-1002802-A1 Dipeptide derivatives as growth hormone secretagogues Pfizer Products Inc. (US) 2000-05-24 EP disclosed