Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 6/20 | 0.42 |
| ▸ | UGCG | Q16739 | 11/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899504 | 1.00 | GHSR (0.42) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL6695238 | 0.89 | GHSR (0.53) | GHSRUGCG | |
| SCHEMBL6694201 | 0.89 | GHSR (0.53) | GHSRUGCG | |
| SCHEMBL6694204 | 0.89 | GHSR (0.53) | GHSRUGCG | |
| SCHEMBL5228589 | 0.84 | GHSR (0.45) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL5230927 | 0.84 | GHSR (0.45) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL5224140 | 0.84 | GHSR (0.44) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL5231715 | 0.84 | GHSR (0.45) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL7903082 | 0.80 | GHSR (0.47) | GHSRUGCGPPARACYP3A4CTSS | |
| SCHEMBL5251052 | 0.79 | GHSR (0.68) | GHSRUGCGPPARACYP3A4CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194578-B1 | GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1002802-A1 | Dipeptide derivatives as growth hormone secretagogues | Pfizer Products Inc. (US) | 2000-05-24 | — | — | EP | disclosed |