SCHEMBL6694492

SCHEMBL6694492

NCn1c(N)nc2ccccc21

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.70
CYP1A2 P05177 1/20 0.70
CYP2D6 P10635 1/20 0.70
CXCR4 P61073 1/20 0.70
POLB P06746 1/20 0.66
TLR8 Q9NR97 3/20 0.62
NOD1 Q9Y239 4/20 0.60
TNF P01375 2/20 0.60
NOD2 Q9HC29 2/20 0.60
CXCL8 P10145 2/20 0.60
SOS1 Q07889 1/20 0.60
NOS2 P35228 1/20 0.57
KMT2A Q03164 3/20 0.54
TP53 P04637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6199065 0.86 CXCR4 (0.85) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL13801517 0.85 CXCR4 (0.77) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL7164854 0.82 CXCR4 (0.93) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL1992429 0.82 CYP1A2 (1.00) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL6196399 0.82 CXCR4 (1.00) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL6197634 0.81 CXCR4 (0.96) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL14447553 0.81 CXCR4 (0.96) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL22121595 0.81 HTT (0.66) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL7165480 0.81 TNF (0.87) HTTCYP1A2CYP2D6CXCR4POLB
SCHEMBL939417 0.79 TNF (0.79) HTTCYP1A2CYP2D6CXCR4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004050035-A2 BENZIMIDAZOLES AND ANALOGS THEREOF AS ANTIVIRALS ISIS PHARMACEUTICALS, INC. (US) 2004-06-17 WO disclosed