Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.79 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.79 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.79 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.79 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.63 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165480 | 0.95 | TNF (0.87) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL7168102 | 0.90 | KMT2A (0.71) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL7337702 | 0.88 | NOD1 (1.00) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL7530572 | 0.88 | TNF (0.72) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL9630558 | 0.87 | TNF (0.75) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL23361962 | 0.85 | KMT2A (0.66) | TNFNOD2NOD1CXCL8SOS1 | |
| Hydrochloric Acid SCHEMBL11594488 | 0.85 | TNF (0.73) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL23362176 | 0.84 | TNF (0.62) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL16512786 | 0.84 | KMT2A (0.64) | TNFNOD2NOD1CXCL8SOS1 | |
| SCHEMBL11715808 | 0.84 | CXCR4 (0.72) | TNFNOD2NOD1CXCL8SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114907733-A | High-corrosion-resistance magnesium-aluminum alloy chromium-free fingerprint-resistant coating liquid and preparation method thereof | 安徽未来表面技术有限公司 | 2022-08-16 | — | — | CN | claimed |
| US-8153385-B2 | Target protein and target gene in drug designing and screening method | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2012-04-10 | — | — | US | claimed |
| US-20100136524-A1 | TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2010-06-03 | — | — | US | claimed |
| CN-114907733-A | High-corrosion-resistance magnesium-aluminum alloy chromium-free fingerprint-resistant coating liquid and preparation method thereof | 安徽未来表面技术有限公司 | 2022-08-16 | — | — | CN | disclosed |
| EP-3467930-B1 | NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY | ASAHI CHEMICAL IND (JP) | 2020-05-13 | — | — | EP | disclosed |
| US-10471139-B2 | Toll-like receptor agonists | THE UNIVERSITY OF KANSAS (US) | 2019-11-12 | — | — | US | disclosed |
| US-10471139-B2 | Toll-like receptor agonists | THE UNIVERSITY OF KANSAS (US) | 2019-11-12 | — | — | US | disclosed |
| EP-3467930-A1 | NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2019-04-10 | — | — | EP | disclosed |
| EP-3279997-A1 | NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY | Asahi Kasei Kabushiki Kaisha (JP) | 2018-02-07 | — | — | EP | disclosed |
| US-9789111-B2 | Casein kinase 1δ (CK 1δ) inhibitors | ELECTROPHORETICS LIMITED (GB) | 2017-10-17 | — | — | US | disclosed |
| US-9789111-B2 | Casein kinase 1δ (CK 1δ) inhibitors | ELECTROPHORETICS LIMITED (GB) | 2017-10-17 | — | — | US | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20050228022-A1 | blocking voltage-sensitive sodium channels of neurons in a mammal comprising administering 1-benzyl-2-imino-3-(2-hydroxy-3-phenoxypropyl)benzimidazole; analgesics; neuroprotectants; anticonvulsants | TAKTIX CORPORATION (US) | 2005-10-13 | — | — | US | disclosed |
| US-20040242627-A1 | 2-Iminoimidazole derivatives (1) | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| EP-1394152-A1 | 2-IMINOIMIDAZOLE DERIVATIVES (1) | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5283243-A | Anti-inflammatory, anti-allergic, hypotensive and vasodilating agents | KALI-CHEMIE PHARMA GMBH (DE) | 1994-02-01 | — | — | US | disclosed |
| EP-0488009-A2 | Piperidinoalkyl-benzoxazine-and-thiazine-compounds, processes for their preparation and drugs containing them | Kali-Chemie Pharma GmbH (DE) | 1992-06-03 | — | — | EP | disclosed |
| US-4593105-A | REACTING ARYLDIAMINE WITH THIOCYANATE | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| US-4083843-A | YELLOW DYE FOR NYLON, POLYACRYLONITRILE, WOOL AND SILK | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | TIE1, KDR, FLT1 | TNF 3815/4885NOD2 2687/4885NOD1 2218/4885 |
| US-20040242627-A1 | 2-Iminoimidazole derivatives (1) | H1-2, H1-0, H1-3 | TNF 4506/4885NOD2 1887/4885NOD1 904/4885 |
| US-20100136524-A1 | TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD | CHP1, CMA1, CARHSP1 | TNF 4125/4885NOD2 1404/4885NOD1 2636/4885 |
| US-10471139-B2 | Toll-like receptor agonists | TLR1, TLR7, TLR8 | TNF 652/4885NOD2 12/4885NOD1 13/4885 |
| US-20050228022-A1 | blocking voltage-sensitive sodium channels of neurons in a mammal comprising administering 1-benzyl-2-imino-3-(2-hydroxy-3-phenoxypropyl)benzimidazole; analgesics; neuroprotectants; anticonvulsants | CACNA1E, CACNA1B, SCN1A | TNF 2979/4885NOD2 2875/4885NOD1 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.