Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 2/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.57 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199065 | 0.90 | CXCR4 (0.85) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL6196399 | 0.87 | CXCR4 (1.00) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL7164854 | 0.87 | CXCR4 (0.93) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL6197634 | 0.85 | CXCR4 (0.96) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL14447553 | 0.85 | CXCR4 (0.96) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL6694492 | 0.85 | HTT (0.70) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL1520381 | 0.84 | POLB (1.00) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL17329351 | 0.82 | CXCR4 (0.72) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL22121330 | 0.82 | CXCR4 (0.72) | CXCR4POLBTLR8HTTCYP1A2 | |
| SCHEMBL11715808 | 0.82 | CXCR4 (0.72) | CXCR4POLBTLR8HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038968-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | COATS STEVEN J (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038968-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | COATS STEVEN J (US) | 2014-02-06 | — | — | US | disclosed |
| US-8324380-B2 | Amino-heteroaryl-containing prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-04 | — | — | US | disclosed |
| US-8324380-B2 | Amino-heteroaryl-containing prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20090163505-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-25 | — | — | US | disclosed |
| US-20090163505-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-25 | — | — | US | disclosed |
| WO-2009058653-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038968-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | PROKR1, PROKR2, GIPR | CXCR4 2311/4885POLB 4287/4885TLR8 3052/4885 |
| US-20090163505-A1 | AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS | PROKR1, PROKR2, GIPR | CXCR4 2311/4885POLB 4287/4885TLR8 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.