Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.35 |
| ▸ | THRB | P10828 | 13/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MRE11 | P49959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691554 | 0.77 | THRA (0.36) | THRATHRBEGLN1 | |
| SCHEMBL6691535 | 0.77 | THRB (0.41) | THRATHRB | |
| SCHEMBL6693202 | 0.76 | THRA (0.54) | THRATHRB | |
| Methane SCHEMBL6690821 | 0.75 | THRA (0.53) | THRATHRB | |
| SCHEMBL6694624 | 0.75 | THRA (0.35) | THRATHRB | |
| SCHEMBL6693947 | 0.74 | THRA (0.35) | THRATHRB | |
| SCHEMBL6694150 | 0.74 | THRA (0.35) | THRATHRB | |
| SCHEMBL6693924 | 0.69 | ATM (0.39) | THRB | |
| SCHEMBL6692008 | 0.68 | THRA (0.58) | THRATHRB | |
| SCHEMBL6695024 | 0.67 | THRA (0.50) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040039028-A1 | Pyridine-based thyroid receptor ligands | BRISTOL-MYERS SQUIBB COMPANY | 2004-02-26 | — | — | US | disclosed |
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039028-A1 | Pyridine-based thyroid receptor ligands | TSHR, THRB, THRA | THRA 3/4885THRB 2/4885VEGFA 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.