Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6696350 | 0.90 | LMNA (0.45) | KMT2ATP53GAANTRK1NTRK2 | |
| SCHEMBL6692260 | 0.90 | TP53 (0.38) | KMT2ANPC1CMA1TP53GAA | |
| SCHEMBL1343555 | 0.87 | TP53 (0.43) | KMT2ANPC1CMA1TP53GAA | |
| SCHEMBL6695858 | 0.85 | TP53 (0.41) | KMT2ANPC1CMA1TP53GAA | |
| SCHEMBL6696343 | 0.84 | ALDH1A1 (0.44) | NPC1TP53GAANTRK1NTRK2 | |
| SCHEMBL6697168 | 0.83 | TP53 (0.42) | KMT2ANPC1TP53GAANTRK1 | |
| SCHEMBL1341776 | 0.83 | NPC1 (0.38) | KMT2ANPC1CMA1TP53SMN1; SMN2 | |
| SCHEMBL1343018 | 0.82 | KMT2A (0.37) | KMT2ANPC1CMA1NTRK1NTRK2 | |
| SCHEMBL6697191 | 0.81 | TP53 (0.44) | KMT2ANPC1TP53GAANTRK1 | |
| SCHEMBL1343075 | 0.81 | TP53 (0.53) | KMT2ANPC1TP53GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | VTV THERAPEUTICS LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | GCK, GCKR, PDK2 | KMT2A 1526/4885NPC1 2201/4885CMA1 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.