Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30451255 | 0.84 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2843958 | 0.81 | HDAC4 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL217745 | 0.80 | HDAC3 (0.71) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14249309 | 0.80 | HDAC3 (0.71) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6866118 | 0.80 | POLB (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Xanthene Carboxylic Acid SCHEMBL30011680 | 0.79 | ATM (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Xanthene Carboxylic Acid SCHEMBL40617 | 0.79 | ATM (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6867060 | 0.78 | KMT2A (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Xanthene Carboxylic Acid SCHEMBL9551091 | 0.77 | ATM (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Xanthene Carboxylic Acid SCHEMBL5780275 | 0.77 | ATM (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264784-A1 | METHODS OF TREATING ELEVATIONS IN MTOR SIGNALING | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2012-10-18 | — | — | US | disclosed |
| EP-2496224-A1 | METHODS OF TREATING ELEVATIONS IN MTOR SIGNALING | Brown University (US) | 2012-09-12 | — | — | EP | disclosed |
| US-20040054195-A1 | Fluorescent dyes; photostability; labels, staining; analysis | NORTHEASTERN UNIVERSITY | 2004-03-18 | — | — | US | disclosed |
| WO-2002055512-A1 | XANTHENE DERIVATIVES | NORTHEASTERN UNIVERSITY (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264784-A1 | METHODS OF TREATING ELEVATIONS IN MTOR SIGNALING | MTOR, RPTOR, GRM1 | HDAC3 632/4885HDAC4 756/4885HDAC1 552/4885 |
| US-20040054195-A1 | Fluorescent dyes; photostability; labels, staining; analysis | ANXA5, XDH, TFEB | HDAC3 2491/4885HDAC4 3832/4885HDAC1 4493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.