Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852366 | 0.88 | GRM5 (0.46) | NOTUMGRM5KAT6AKDM4EALDH1A1 | |
| SCHEMBL3103821 | 0.80 | NOTUM (0.58) | NOTUMGRM5KAT6AKDM4EALDH1A1 | |
| SCHEMBL3302913 | 0.78 | GRM5 (0.46) | NOTUMGRM5KDM4EALDH1A1MAPK1 | |
| SCHEMBL18865611 | 0.78 | NOTUM (0.53) | NOTUMGRM5ARKDM4EALDH1A1 | |
| SCHEMBL17594887 | 0.78 | GRM5 (0.49) | NOTUMGRM5KDM4EALDH1A1MAPK1 | |
| SCHEMBL31376000 | 0.78 | NOTUM (0.45) | NOTUMGRM5KDM4EALDH1A1MAPK1 | |
| SCHEMBL3639674 | 0.78 | NOTUM (0.45) | NOTUMGRM5KDM4EALDH1A1MAPK1 | |
| SCHEMBL7091332 | 0.78 | SCN9A (0.52) | ARSCN9A | |
| SCHEMBL8397313 | 0.78 | KDM4E (0.53) | NOTUMGRM5KDM4EALDH1A1MAPK1 | |
| SCHEMBL3909664 | 0.78 | ALDH1A1 (0.46) | NOTUMGRM5KDM4EALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235575-B2 | Guanidine mimics as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-06-26 | — | — | US | disclosed |
| CN-1610679-A | Efficient process for the preparation of a factor XA inhibitor | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2005-04-27 | — | — | CN | disclosed |
| US-20040198787-A1 | Efficient process for the preparation of a factor Xa inhibitor | LI HUI-YIN (US) | 2004-10-07 | — | — | US | disclosed |
| US-6747158-B2 | ANTICOAGULANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-06-08 | — | — | US | disclosed |
| US-6667332-B2 | Benzisoxazolyl-pyrazole derivatives formed by salt formation with maleic acid and hydrochloric acid and cyclization with acetohydroxamic acid | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-23 | — | — | US | disclosed |
| EP-1366045-A2 | EFFICIENT PROCESS FOR THE PREPARATION OF A FACTOR XA INHIBITOR | Bristol-Myers Squibb Pharma Company (US) | 2003-12-03 | — | — | EP | disclosed |
| US-20030212117-A1 | Efficient process for the preparation of a factor Xa inhibitor | LI HUI-YIN (US) | 2003-11-13 | — | — | US | disclosed |
| WO-2002024690-A3 | EFFICIENT PROCESS FOR THE PREPARATION OF A FACTOR XA INHIBITOR | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-09-25 | — | — | WO | disclosed |
| WO-2002024690-A8 | EFFICIENT PROCESS FOR THE PREPARATION OF A FACTOR XA INHIBITOR | DU PONT PHARM CO (US) | 2002-08-08 | — | — | WO | disclosed |
| US-20020061917-A1 | Efficient process for the preparation of a factor Xa inhibitor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-05-23 | — | — | US | disclosed |
| WO-2002024690-A2 | EFFICIENT PROCESS FOR THE PREPARATION OF A FACTOR XA INHIBITOR | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212117-A1 | Efficient process for the preparation of a factor Xa inhibitor | TFPI, F11, F12 | NOTUM 999/4885GRM5 4462/4885KAT6A 3259/4885 |
| US-20040198787-A1 | Efficient process for the preparation of a factor Xa inhibitor | TFPI, F11, F12 | NOTUM 999/4885GRM5 4462/4885KAT6A 3259/4885 |
| US-20020061917-A1 | Efficient process for the preparation of a factor Xa inhibitor | TFPI, F11, F12 | NOTUM 999/4885GRM5 4462/4885KAT6A 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.