⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461473 | 0.78 | — | — | |
| SCHEMBL6247062 | 0.73 | L3MBTL1 (0.33) | — | |
| SCHEMBL9846338 | 0.72 | — | — | |
| SCHEMBL6445897 | 0.70 | — | — | |
| SCHEMBL3237407 | 0.70 | FDPS (0.45) | — | |
| SCHEMBL28655698 | 0.68 | FDPS (0.37) | — | |
| SCHEMBL9472904 | 0.67 | — | — | |
| SCHEMBL2638437 | 0.67 | — | — | |
| SCHEMBL14840392 | 0.67 | — | — | |
| SCHEMBL1717782 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020105054-A9 | MODIFIED AMINOGLYCOSIDE COMPOUNDS AND USES THEREOF IN DISABLING BACTERIAL RIBOSOME | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2020-11-05 | — | — | WO | disclosed |
| US-20040192780-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2004-09-30 | — | — | US | disclosed |
| US-20030236201-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2003-12-25 | — | — | US | disclosed |
| US-6403648-B2 | RENIN INHIBITOR | G. D. SEARLE & CO. | 2002-06-11 | — | — | US | disclosed |
| US-20020010214-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2002-01-24 | — | — | US | disclosed |
| US-6291529-B1 | RENIN INHIBITORS; TREATING GLAUCOMA | G. D. SEARLE & CO. | 2001-09-18 | — | — | US | disclosed |
| US-20010011101-A1 | Alkylaminoalkyl-sulfonyl-terminated Beta-alanineamide amino-diol compounds for treatment of hypertension | HANSON GUNNAR J (US) | 2001-08-02 | — | — | US | disclosed |
| US-5968984-A | Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5756549-A | RENIN INHIBITORS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5488067-A | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5461074-A | Dipropargyl containing aryl/alkyl sulfur/or sulfonyl/or sulfoxide terminated aminodiol compounds are used as renin inhibitor; therpeutical | G.D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| US-5432201-A | Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-07-11 | — | — | US | disclosed |
| US-5416119-A | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5414018-A | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-05-09 | — | — | US | disclosed |
| WO-1995008531-A1 | ALKYLAMINOALKYL-TERMINATED SULFIDE/SULFONYL-CONTAINING PROPARGYL AMINO-DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1995-03-30 | — | — | WO | disclosed |
| US-5317039-A | Renin inhibitors with peptides | G. D. SEARLE & CO. (US) | 1994-05-31 | — | — | US | disclosed |
| US-5314920-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | disclosed |
| US-5312838-A | β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1994-05-17 | — | — | US | disclosed |
| US-5268391-A | Cardiovascular disorders | C. D. SEARLE & CO. (US) | 1993-12-07 | — | — | US | disclosed |
| US-5246969-A | Oligopeptides as renin inhibitors | G. D. SEARLE & CO. (US) | 1993-09-21 | — | — | US | disclosed |