Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.66 |
| ▸ | ALPL | P05186 | 4/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DCUN1D2 | Q6PH85 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10944351 | 0.70 | NR1H2 (0.77) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL8725571 | 0.68 | DCUN1D1 (0.62) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL6979117 | 0.66 | DCUN1D1 (0.57) | DCUN1D1ALPLLMNAALPGALDH1A1 | |
| SCHEMBL6979120 | 0.65 | DCUN1D1 (0.56) | DCUN1D1ALPLLMNAALPG | |
| SCHEMBL21456835 | 0.63 | BTK (0.55) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL646494 | 0.63 | NR1H2 (0.76) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL10335420 | 0.62 | KIF11 (0.33) | ALDH1A1 | |
| SCHEMBL5959950 | 0.62 | SMN1; SMN2 (0.69) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL8841399 | 0.61 | DCUN1D1 (0.51) | DCUN1D1ALPLNR1H2NR1H3NPC1 | |
| SCHEMBL9831523 | 0.61 | NR1H2 (0.57) | DCUN1D1ALPLNR1H2NR1H3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214864-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2004-10-28 | — | — | US | disclosed |
| EP-1109790-B1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| EP-1274694-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-20020086862-A1 | Novel compounds | ASTRAZENECA AB | 2002-07-04 | — | — | US | disclosed |
| WO-2001077087-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-18 | — | — | WO | disclosed |
| EP-1109790-A1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012489-A1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086862-A1 | Novel compounds | ABCG2, CYP3A4, CYP4B1 | DCUN1D1 2840/4885ALPL 4282/4885NR1H2 694/4885 |
| US-20040214864-A1 | Novel compounds | ABCG2, CYP3A4, CYP4B1 | DCUN1D1 2840/4885ALPL 4282/4885NR1H2 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.