Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.52 |
| ▸ | FAAH | O00519 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576775 | 1.00 | POLB (0.60) | POLBRAB9ANPC1KDM4ETRPV1 | |
| SCHEMBL13366272 | 0.85 | RAB9A (0.64) | RAB9ANPC1KDM4ETRPV1FAAH | |
| SCHEMBL4559135 | 0.85 | SMN1; SMN2 (0.51) | POLBRAB9ANPC1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28230855 | 0.85 | POLB (0.61) | POLBRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL20886932 | 0.82 | POLB (0.55) | POLBRAB9ANPC1KDM4ETRPV1 | |
| SCHEMBL653099 | 0.82 | TAS1R3 (0.62) | POLBKDM4EFAAHSMN1; SMN2KMT2A | |
| SCHEMBL30965826 | 0.82 | TAS1R3 (0.62) | POLBKDM4EFAAHSMN1; SMN2KMT2A | |
| SCHEMBL20236493 | 0.81 | RAB9A (0.59) | RAB9ANPC1KDM4ETRPV1FAAH | |
| SCHEMBL22218315 | 0.81 | KDM4E (0.65) | RAB9ANPC1KDM4ETRPV1FAAH | |
| SCHEMBL28269904 | 0.81 | KMT2A (0.68) | RAB9ANPC1KDM4ETRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |