Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GMNN | O75496 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6699082 | 0.81 | FAAH (0.51) | FFAR1FFAR4MEN1KMT2AFAAH | |
| SCHEMBL10538656 | 0.81 | MEN1 (0.44) | SPHK1SLC6A5FFAR1FFAR4MEN1 | |
| SCHEMBL4018634 | 0.80 | FFAR1 (0.49) | FFAR1FFAR4MEN1KMT2AFAAH | |
| SCHEMBL18780549 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL21031424 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL23667838 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL22276357 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL22276133 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL18780501 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 | |
| SCHEMBL23667899 | 0.80 | SPHK1 (0.50) | SPHK1FFAR1FFAR4TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | claimed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | claimed |
| WO-2004096864-A2 | RUBBER COMPOSITION CONTAINING A SILICA DISPERSION AGENT | EKT TECHNOLOGIES, LLC (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20040214929-A1 | Rubber composition containing a silica dispersion agent | BRADLEY ROBERT (US) | 2004-10-28 | — | — | US | disclosed |
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | disclosed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | disclosed |