Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.51 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6699079 | 0.81 | SPHK1 (0.42) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL4018634 | 0.77 | FFAR1 (0.49) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL19115281 | 0.76 | FAAH (0.61) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL29937643 | 0.76 | FAAH (0.56) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL29100430 | 0.76 | FAAH (0.61) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL21654255 | 0.76 | FAAH (0.61) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL6897483 | 0.76 | FAAH (0.59) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL6748934 | 0.76 | FAAH (0.59) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL7854030 | 0.76 | FAAH (0.59) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL7854038 | 0.76 | FAAH (0.59) | FAAHSOAT1CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | claimed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | claimed |
| WO-2004096864-A2 | RUBBER COMPOSITION CONTAINING A SILICA DISPERSION AGENT | EKT TECHNOLOGIES, LLC (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20040214929-A1 | Rubber composition containing a silica dispersion agent | BRADLEY ROBERT (US) | 2004-10-28 | — | — | US | disclosed |
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1288255-A1 | Silica reinforced rubber composition and article of manufacture, including such | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | disclosed |
| US-6476115-B1 | SILICA REINFORCED RUBBER COMPOSITION WHICH CONTAINS OLEYLAMMONIUM BROMIDE AND/OR MERCAPTOIMIDAZOLIUM BROMIDE COUPLING AGENTS TO ENHANCE ELECTRICAL CONDUCTIVITY AND ARTICLE OF MANUFACTURE, INCLUDING A TIRE, HAVING AT LEAST ONE COMPONENT COMPRISED OF SUCH RUBBER COMPOSITION | THE GOODYEAR TIRE & RUBBER COMPANY | 2002-11-05 | — | — | US | disclosed |