SCHEMBL6699155

SCHEMBL6699155

COC(=O)C[N+]1(CCCNC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 20/20 0.63
HTR2A P28223 4/20 0.63
SLC6A2 P23975 1/20 0.60
SLC6A4 P31645 1/20 0.60
SLC6A3 Q01959 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL6217023 0.99 CCR3 (0.62) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL7972807 0.86 CCR3 (0.60) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL6337473 0.83 CCR3 (0.43) CCR3HTR2ASLC6A2SLC6A4SLC6A3
Bromide SCHEMBL6217021 0.77 MGLL (0.40) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL6215640 0.77 CCR3 (1.00) CCR3HTR2A
SCHEMBL6337783 0.77 CCR3 (1.00) CCR3HTR2A
SCHEMBL6780545 0.75 CCR3 (1.00) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL6780550 0.75 CCR3 (1.00) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL7656814 0.75 CCR3 (1.00) CCR3HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL7656820 0.75 CCR3 (1.00) CCR3HTR2ASLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6780857-B2 FOR TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES SUCH AS ASTHMA AND ALLERGIC DISEASES, AS WELL AS AUTOIMMUNE PATHOLOGIES SUCH AS RHEUMATOID ARTHRITIS AND ATHEROSCLEROSIS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-08-24 US disclosed
US-20040006107-A1 N-ureidoalkyl-piperidines as modulators of chemokine receptor activity KO SOO S (US) 2004-01-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040006107-A1 N-ureidoalkyl-piperidines as modulators of chemokine receptor activity CCR3, CCR1, CCR10 CCR3 1/4885HTR2A 1608/4885SLC6A2 3476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.