Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | GMPS | P49915 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | ILK | Q13418 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL668383 | 0.80 | EGFR (0.80) | EGFRFBP1LCKKDR | |
| Hydrochloric Acid SCHEMBL668222 | 0.80 | EGFR (0.80) | EGFRFBP1LCKKDR | |
| SCHEMBL668559 | 0.75 | EGFR (1.00) | EGFRABCG2LCKAURKBKDR | |
| SCHEMBL10101851 | 0.74 | EGFR (0.71) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL22336685 | 0.73 | EGFR (0.79) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL31167366 | 0.73 | EGFR (0.73) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL1507676 | 0.73 | EGFR (0.73) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL31167368 | 0.73 | EGFR (0.73) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL31632932 | 0.72 | EGFR (0.67) | EGFRABCG2FBP1LCKAURKB | |
| SCHEMBL7119658 | 0.72 | FBP1 (1.00) | EGFRFBP1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046461-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | NORTHEASTERN UNIVERSITY (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2010085747-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | NORTHEASTERN UNIVERSITY (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046461-A1 | STEROIDAL ANTI-HORMONE HYBRIDS | ESRRA, ESRRB, NR5A1 | EGFR 768/4885ABCG2 2837/4885FBP1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.