Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 6/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | MPO | P05164 | 4/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.48 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693510 | 0.90 | RAD52 (1.00) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695258 | 0.86 | RAD52 (0.72) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6693275 | 0.86 | KMT2A (0.81) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6699511 | 0.86 | RAD52 (0.81) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695603 | 0.85 | RAD52 (0.74) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695896 | 0.85 | RAD52 (0.74) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695249 | 0.84 | KDM4E (0.71) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL27571655 | 0.83 | RAD52 (0.76) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695085 | 0.81 | KMT2A (0.79) | RAD52ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6695186 | 0.81 | KMT2A (0.77) | RAD52ALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | NHERF1, SLC9A3, SLC9A1 | RAD52 4856/4885ALDH1A1 875/4885KMT2A 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.