Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5890324 | 0.87 | MAPK10 (0.38) | EIF2AK2GSK3BDYRK1ACLK1CLK2 | |
| SCHEMBL5890754 | 0.86 | EIF2AK2 (0.49) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5890058 | 0.86 | EIF2AK2 (0.49) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5890132 | 0.85 | EIF2AK2 (0.49) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5564752 | 0.85 | EIF2AK2 (0.52) | EIF2AK2GSK3BMAPK10CDK1CSNK1D | |
| SCHEMBL6106995 | 0.84 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10KDRCDK5 | |
| SCHEMBL6106606 | 0.84 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10KDRCDK5 | |
| SCHEMBL6105305 | 0.83 | EIF2AK2 (0.51) | EIF2AK2GSK3BMAPK10KDRCDK5 | |
| SCHEMBL5890307 | 0.82 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL6108267 | 0.81 | GSK3B (0.51) | EIF2AK2GSK3BMAPK10KDRCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142941-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142941-A1 | Therapeutic compounds | PCSK9, ABCB1, ABCB11 | EIF2AK2 3551/4885GSK3B 1245/4885DYRK1A 4644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.