Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29103166 | 1.00 | CA4 (0.48) | CA4CA1CA2CA7CA9 | |
| SCHEMBL23152667 | 0.98 | CA1 (0.50) | CA4CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL29103161 | 0.96 | CA4 (0.48) | CA4CA1CA2CA7CA9 | |
| SCHEMBL17996980 | 0.80 | CA1 (0.50) | CA1CA2CA7CA9CA12 | |
| SCHEMBL776579 | 0.78 | NPC1 (0.37) | CA1CA2CA9ACHENPC1 | |
| Hydrochloric Acid SCHEMBL8984976 | 0.78 | NQO1 (0.54) | CA1CA2CA7CA9CA12 | |
| 1,4-Dimethoxybenzene SCHEMBL27781098 | 0.75 | CA1 (0.85) | CA4CA1CA2CA7CA9 | |
| SCHEMBL13918083 | 0.75 | KDM4E (0.51) | ACHEBCHENPC1RAB9AGAA | |
| Hydrochloric Acid SCHEMBL4727803 | 0.75 | ACHE (0.42) | CA2ACHEBCHENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL29103228 | 0.75 | ACHE (0.42) | CA2ACHEBCHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790588-B2 | Imagable articles and compositions therefor | KODAK POLYCHROME GRAPHICS LLC | 2004-09-14 | — | — | US | disclosed |
| US-20040048186-A1 | Imagable articles and compositions therefor | KODAK POLYCHROME GRAPHICS LLC. | 2004-03-11 | — | — | US | disclosed |