Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668661 | 0.77 | TRPM5 (0.38) | RAF1FDPS | |
| SCHEMBL670261 | 0.76 | MCHR1 (0.35) | RAF1 | |
| SCHEMBL669609 | 0.76 | MEN1 (0.38) | RAF1MAPK14ALDH1A1 | |
| SCHEMBL670262 | 0.75 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL668932 | 0.74 | KDM4C (0.39) | RAF1MAPK14ABL1SRC | |
| SCHEMBL669903 | 0.74 | RAF1 (0.44) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL669157 | 0.73 | RAF1 (0.37) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1441015 | 0.72 | RAF1 (0.33) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL669880 | 0.72 | RAF1 (0.36) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10206102 | 0.71 | SMN1; SMN2 (0.39) | RAF1MAPK14ALDH1A1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606041-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024363-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-23 | — | — | WO | disclosed |