Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4835390 | 0.72 | KDM4E (0.36) | NR3C2KDR | |
| SCHEMBL4830870 | 0.66 | PGR (0.43) | — | |
| SCHEMBL4831474 | 0.60 | CA1 (0.46) | KDR | |
| SCHEMBL4829037 | 0.60 | GAA (0.45) | KDR | |
| SCHEMBL4826356 | 0.56 | CYP1A2 (0.34) | NR3C2 | |
| SCHEMBL6632966 | 0.55 | IKBKB (0.41) | — | |
| SCHEMBL1574162 | 0.53 | MEN1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL28052562 | 0.53 | NPC1 (0.95) | — | |
| SCHEMBL1439894 | 0.53 | TYK2 (0.52) | — | |
| SCHEMBL1467307 | 0.53 | HNF4A (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425284-A2 | FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022852-A2 | FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-20 | — | — | WO | disclosed |