Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.53 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698909 | 0.87 | S1PR5 (0.40) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6693912 | 0.86 | MMP13 (0.50) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6689447 | 0.85 | MMP1 (0.38) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6691935 | 0.84 | MMP13 (0.60) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6693818 | 0.76 | MMP13 (0.71) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6689106 | 0.73 | S1PR5 (0.41) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6701978 | 0.72 | MMP13 (0.56) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6692070 | 0.72 | MMP13 (0.51) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6693304 | 0.71 | MMP13 (0.58) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6690306 | 0.70 | MMP1 (0.45) | MMP13MMP2MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |