Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.67 |
| ▸ | PARG | Q86W56 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 12/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703371 | 0.76 | PARG (0.53) | PARP1PARGBRD4RXFP1 | |
| SCHEMBL6694764 | 0.72 | PARP1 (1.00) | PARP1PARGBRD4RXFP1KDM4E | |
| Hydrochloric Acid SCHEMBL6686733 | 0.71 | PARP1 (1.00) | PARP1PARGBRD4RXFP1KDM4E | |
| SCHEMBL6685976 | 0.70 | PARP1 (0.81) | PARP1PARGALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6686732 | 0.70 | PARP1 (0.96) | PARP1PARGBRD4RXFP1KDM4E | |
| SCHEMBL6693963 | 0.65 | BRD4 (0.81) | BRD4 | |
| SCHEMBL6531769 | 0.64 | NEK1 (0.58) | HPGD | |
| SCHEMBL12577305 | 0.63 | BRAF (0.55) | PARP1BRAFKDM4EALDH1A1HPGD | |
| SCHEMBL15935048 | 0.62 | PARP1 (0.64) | PARP1BRD4KDM4EALDH1A1 | |
| SCHEMBL10988164 | 0.61 | GAA (0.49) | PARP1BRAFALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723733-B2 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS, INC. | 2004-04-20 | — | — | US | disclosed |
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | EISAI INC. | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | PARP1, PARP2, PARP6 | PARP1 1/4885PARG 52/4885BRD4 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.