Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.96 |
| ▸ | PARG | Q86W56 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694764 | 0.98 | PARP1 (1.00) | PARP1PARGSIGMAR1TP53MAPK1 | |
| Hydrochloric Acid SCHEMBL6686733 | 0.97 | PARP1 (1.00) | PARP1PARGSIGMAR1TP53MAPK1 | |
| SCHEMBL6685976 | 0.88 | PARP1 (0.81) | PARP1PARGMAPK1 | |
| SCHEMBL2763303 | 0.77 | PARP1 (0.75) | PARP1SIGMAR1 | |
| SCHEMBL6337236 | 0.74 | HTR7 (0.68) | PARP1SIGMAR1 | |
| SCHEMBL4196782 | 0.73 | SIGMAR1 (0.73) | PARP1SIGMAR1KDM4ELMNAMAPT | |
| SCHEMBL6340577 | 0.72 | HTR7 (0.70) | PARP1SIGMAR1 | |
| SCHEMBL4617661 | 0.71 | SFRP1 (0.61) | PARP1SIGMAR1TP53MAPK1KDM4E | |
| SCHEMBL6568486 | 0.71 | SIGMAR1 (0.72) | PARP1SIGMAR1KDM4ELMNAMAPT | |
| SCHEMBL6703368 | 0.70 | PARP1 (0.67) | PARP1PARGRXFP1KDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723733-B2 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS, INC. | 2004-04-20 | — | — | US | disclosed |
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | EISAI INC. | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | PARP1, PARP2, PARP6 | PARP1 1/4885PARG 52/4885SIGMAR1 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.