Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30185516 | 1.00 | HDAC6 (0.66) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30185511 | 0.89 | HDAC6 (0.67) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL28586566 | 0.89 | HDAC6 (0.67) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30185500 | 0.89 | HDAC6 (0.78) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL6086357 | 0.89 | HDAC6 (0.65) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL28582440 | 0.89 | HDAC6 (0.78) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30185520 | 0.89 | HDAC6 (0.65) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL14120698 | 0.88 | HDAC6 (0.65) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL29738358 | 0.87 | HDAC6 (0.56) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL28773999 | 0.87 | HDAC6 (0.56) | HDAC6HDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759541-B | Indole-like derivatives and uses thereof | 复旦大学 | 2023-03-17 | — | — | CN | disclosed |
| CN-112759541-A | Indole-like derivatives and uses thereof | 复旦大学 | 2021-05-07 | — | — | CN | disclosed |
| US-20040067998-A1 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition | YANG JI CHEMICAL COMPANY LTD (KR) | 2004-04-08 | — | — | US | disclosed |
| CN-1473160-A | Indole derivatives as medicinal compositions for antifungal and/or antiparasitic agents | 杨池化学有限公司 | 2004-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067998-A1 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition | IDO1, IDO2, TPH1 | HDAC6 54/4885HDAC8 646/4885HDAC3 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.