Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877743 | 0.79 | CHRM2 (0.51) | OPRL1HSD17B10CHRM2CHRM4CHRM5 | |
| SCHEMBL6911078 | 0.77 | OPRL1 (0.71) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6709096 | 0.77 | OPRL1 (0.63) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL2877688 | 0.75 | OPRL1 (0.77) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL3216799 | 0.74 | OPRM1 (0.47) | OPRL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1411499 | 0.74 | OPRL1 (1.00) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL2883677 | 0.73 | OPRL1 (0.66) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL10916463 | 0.73 | OPRL1 (0.70) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6042326 | 0.73 | OPRL1 (0.66) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6042648 | 0.73 | OPRL1 (0.56) | OPRL1POLBCCR3CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | SMITHKLINE BEECHAM CORPORATION | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | LDLR, NR1H2, NCOR1 | OPRL1 303/4885POLB 3619/4885CCR3 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.