Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6709310 | 0.90 | DRD2 (0.51) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL6709241 | 0.87 | HTR1A (0.62) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL6710778 | 0.86 | DRD2 (0.58) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL3378367 | 0.82 | DRD2 (0.46) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL8042421 | 0.80 | DRD2 (0.63) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL8042425 | 0.80 | DRD2 (0.63) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL3378363 | 0.79 | HTR1A (0.46) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL6784528 | 0.77 | HTR1A (0.51) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL5937286 | 0.77 | HTR1A (0.51) | DRD2HTR1AALDH1A1HTR7MEN1 | |
| SCHEMBL6789308 | 0.76 | DRD2 (0.58) | DRD2HTR1AALDH1A1HTR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147557-A1 | Aryl piperidine derivatives as inducers of ldl-receptor expression | BOUILLOT ANNE (FR) | 2004-07-29 | — | — | US | disclosed |
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | SMITHKLINE BEECHAM CORPORATION | 2004-04-22 | — | — | US | disclosed |
| US-6673555-B1 | USE OF SREBP CLEAVAGE-ACTIVATING PROTEIN (SCAP) TO SCREEN FOR AGENTS HAVING SCAP BINDING CHARACTERISTICS; USE IN COMBATING DISEASES ASSOCIATED WITH ELEVATED BLOOD LIPID LEVELS; SREBP: STEROL REGULATORY ELEMENT BINDING PROTEIN | SMITHKLINE BEECHAM CORPORATION | 2004-01-06 | — | — | US | disclosed |
| US-20030224347-A1 | Pharmaceutical compositions | GRAND-PERRET THIERRY ANDRE REG (FR) | 2003-12-04 | — | — | US | disclosed |
| US-20030224348-A1 | Methods of screening for SCAP antagonists | GRAND-PERRET THIERRY ANDRE REG (FR) | 2003-12-04 | — | — | US | disclosed |
| EP-1196783-A2 | SCREENING FOR THERAPEUTIC AGENTS BEING SCAP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001006261-A2 | SCREENING FOR THERAPEUTIC AGENTS BEING SCAP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147557-A1 | Aryl piperidine derivatives as inducers of ldl-receptor expression | NR1H2, NR1H3, NR1H4 | DRD2 152/4885HTR1A 223/4885ALDH1A1 1002/4885 |
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | LDLR, NR1H2, NCOR1 | DRD2 1008/4885HTR1A 959/4885ALDH1A1 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.