Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389881 | 0.87 | TDP1 (0.53) | TDP1MEN1KMT2AACP3MTNR1A | |
| SCHEMBL7297659 | 0.81 | CYP1A2 (0.43) | TDP1MEN1KMT2AACP3MTNR1A | |
| SCHEMBL5830944 | 0.81 | CYP2C19 (0.56) | TDP1MEN1KMT2AACP3CYP1A2 | |
| SCHEMBL18242791 | 0.78 | CYP2C19 (0.47) | TDP1MEN1KMT2AACP3CYP1A2 | |
| SCHEMBL30258002 | 0.78 | IAPP (0.56) | TDP1ACP3MTNR1ACYP1A2CYP2D6 | |
| SCHEMBL4070601 | 0.78 | IAPP (0.56) | TDP1ACP3MTNR1ACYP1A2CYP2D6 | |
| SCHEMBL5609945 | 0.77 | TDP1 (0.53) | TDP1MEN1KMT2AACP3MTNR1A | |
| SCHEMBL7058290 | 0.76 | MTNR1A (0.45) | TDP1ACP3MTNR1AATM | |
| SCHEMBL10391165 | 0.76 | TDP1 (0.49) | TDP1MEN1KMT2AACP3MTNR1A | |
| SCHEMBL18243028 | 0.76 | CYP2C19 (0.44) | TDP1ACP3CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |