Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30566004 | 0.78 | EGFR (0.35) | MAPTALDH1A1GAACCR4TDP1 | |
| SCHEMBL25250578 | 0.78 | EGFR (0.35) | MAPTALDH1A1GAACCR4TDP1 | |
| SCHEMBL670542 | 0.74 | GAA (0.41) | MAPTALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8231479 | 0.74 | GLS (0.44) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL16100279 | 0.72 | CYP1A2 (0.41) | MAPTALDH1A1NPSR1GAAMEN1 | |
| SCHEMBL673690 | 0.70 | ALDH1A1 (0.48) | MAPTALDH1A1NPSR1PKMTDP1 | |
| SCHEMBL13557319 | 0.67 | CNR2 (0.46) | MAPTALDH1A1GAACCR4POLB | |
| SCHEMBL12643071 | 0.67 | NPC1 (0.56) | MAPTALDH1A1TDP1POLBL3MBTL1 | |
| SCHEMBL28347009 | 0.66 | CNR2 (0.46) | ALDH1A1TDP1L3MBTL1CNR2CNR1 | |
| SCHEMBL1093104 | 0.65 | ALDH1A1 (0.51) | MAPTALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |