SCHEMBL6708764

SCHEMBL6708764

Cn1c(C(=O)Nc2ccc(C#N)cc2-c2noc(=O)[nH]2)cc2c(Br)cc(Br)c(N)c21

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.32
GPR35 Q9HC97 1/20 0.31
F11 P03951 1/20 0.31
KLKB1 P03952 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710110 0.90 GRIK1 (0.32) GRIK1GPR35F11KLKB1
SCHEMBL6707814 0.89 GRIK1 (0.33) GRIK1GPR35F11KLKB1
SCHEMBL6710260 0.89 GRIK1 (0.38) GRIK1GPR35F11
SCHEMBL6709886 0.88 GRIK1 (0.42) GRIK1F11KLKB1
SCHEMBL6710244 0.84 PARP14 (0.34) GRIK1GPR35
SCHEMBL6708831 0.84 GRIK1 (0.36) GRIK1F11KLKB1
SCHEMBL6707739 0.84
SCHEMBL6709930 0.82 PARP14 (0.37) GPR35
SCHEMBL6711649 0.79 GRIK1 (0.33) GRIK1F11KLKB1
SCHEMBL6708719 0.79 GRIK1 (0.38) GRIK1GPR35F11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 GRIK1 3885/4885GPR35 2928/4885F11 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.