Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Cyclohexanone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.61 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclooctanone SCHEMBL28121636 | 0.88 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1 | |
| Cyclohexanone SCHEMBL29032564 | 0.88 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1 | |
| Cyclohexanone SCHEMBL28691080 | 0.86 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1 | |
| Methyl Alcohol SCHEMBL5716663 | 0.82 | TRIM24 (0.79) | TRIM24TRIM33ALDH1A1KMT2ACA2 | |
| Cyclohexanone SCHEMBL16238114 | 0.82 | TRIM24 (0.79) | TRIM24TRIM33ALDH1A1KMT2ACA2 | |
| Cyclohexanone SCHEMBL1961575 | 0.82 | — | — | |
| Cyclohexanone SCHEMBL28313315 | 0.81 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1 | |
| Cyclohexanone SCHEMBL27541062 | 0.79 | TRIM24 (0.73) | TRIM24TRIM33ALDH1A1KMT2ACA2 | |
| Cyclohexanone SCHEMBL10924657 | 0.79 | TRIM24 (0.73) | TRIM24TRIM33ALDH1A1KMT2ACA2 | |
| Cyclopentanone SCHEMBL21611329 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605772-B1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNAT AG (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-20150259284-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNATIONAL SA (CH) | 2015-09-17 | — | — | US | disclosed |
| US-9006460-B2 | Process for preparing aminocyclohexyl ether compounds | CARDIOME INTERNATIONAL AG (CH) | 2015-04-14 | — | — | US | disclosed |
| EP-2605772-A2 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130149751-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME INTERNATIONAL SA (CH) | 2013-06-13 | — | — | US | disclosed |
| WO-2012024100-A2 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259284-A1 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP3A43, CYP4B1, CYP3A4 | TRIM24 2772/4885TRIM33 2483/4885ALDH1A1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.