Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19919908 | 0.87 | TSHR (0.55) | TSHRPOLBTDP1SMN1; SMN2HSD17B10 | |
| SCHEMBL20903627 | 0.87 | TSHR (0.55) | TSHRPOLBTDP1SMN1; SMN2HSD17B10 | |
| SCHEMBL6712789 | 0.86 | TDP1 (0.53) | TSHRPOLBTDP1SMN1; SMN2HSD17B10 | |
| SCHEMBL19051607 | 0.85 | TP53 (0.53) | TSHRPOLBSMN1; SMN2TP53BCHE | |
| SCHEMBL6960913 | 0.85 | SMN1; SMN2 (0.64) | TSHRPOLBTDP1SMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL7427148 | 0.84 | SMN1; SMN2 (0.62) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL1723877 | 0.83 | TSHR (0.51) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL18381265 | 0.82 | HTT (0.46) | POLBTDP1SMN1; SMN2TP53 | |
| SCHEMBL10602511 | 0.81 | TSHR (0.49) | TSHRPOLBTDP1SMN1; SMN2KMT2A | |
| SCHEMBL7366845 | 0.80 | TSHR (0.50) | TSHRPOLBTDP1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |