Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255222 | 0.86 | ALDH1A1 (0.47) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL137042 | 0.75 | ALDH1A1 (0.69) | ALDH1A1POLBKMT2ATLR8CA12 | |
| Hydrochloric Acid SCHEMBL14673192 | 0.74 | ALDH1A1 (0.67) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL462620 | 0.72 | ESR1 (0.60) | ALDH1A1POLBKMT2ACA12CA1 | |
| SCHEMBL10005373 | 0.71 | ALDH1A1 (0.74) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL11009084 | 0.70 | ALDH1A1 (0.67) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL6017638 | 0.70 | NISCH (0.38) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL6767282 | 0.70 | TLR8 (0.67) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL12296988 | 0.69 | ALDH1A1 (0.65) | ALDH1A1POLBKMT2ATLR8CA12 | |
| SCHEMBL141000 | 0.69 | TLR8 (0.51) | ALDH1A1POLBKMT2ATLR8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248615-A4 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | ALTEON INC (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-1248615-A1 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | Alteon, Inc. (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001052847-A1 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | ALTEON, INC. (US) | 2001-07-26 | — | — | WO | disclosed |