Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660261 | 0.72 | MAOB (0.30) | — | |
| SCHEMBL15821809 | 0.69 | ALDH1A1 (0.38) | CYP3A4HTR1DHTR1BHPGD | |
| SCHEMBL670896 | 0.69 | MEN1 (0.44) | TSHRTDP1LMNAHPGDHTT | |
| SCHEMBL21777750 | 0.68 | MAPT (0.33) | — | |
| SCHEMBL7969500 | 0.68 | HTR1D (0.40) | CYP3A4TSHRTDP1HTR1DHTR1B | |
| SCHEMBL658037 | 0.67 | PGK1 (0.34) | — | |
| SCHEMBL9028451 | 0.67 | SELL (0.39) | TDP1LMNAHPGDHTTNPSR1 | |
| SCHEMBL9029561 | 0.66 | PTGS1 (0.43) | HTR1DHTR1BGABRA1GABRB2LMNA | |
| SCHEMBL2967307 | 0.65 | KDM4E (0.42) | CYP3A4NPSR1 | |
| SCHEMBL12305002 | 0.65 | HTR1D (0.41) | HTR1DHTR1BPRNPHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |