Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.56 |
| ▸ | CTSB | P07858 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.38 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.38 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.38 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6711500 | 1.00 | AR (0.56) | ARCTSBGAAHTR1AMAPT | |
| SCHEMBL3619196 | 0.79 | AR (0.61) | ARCTSBGAAMAPTHTT | |
| SCHEMBL4872032 | 0.79 | AR (0.61) | ARCTSBGAAMAPTHTT | |
| SCHEMBL3619197 | 0.79 | AR (0.61) | ARCTSBGAAMAPTHTT | |
| SCHEMBL3624869 | 0.76 | CTSB (0.69) | ARCTSBGAAMAPTHTT | |
| SCHEMBL17599487 | 0.75 | CTSB (0.59) | ARCTSBTDP1ALDH1A1LMNA | |
| SCHEMBL17599443 | 0.75 | CTSB (0.59) | ARCTSBTDP1ALDH1A1LMNA | |
| SCHEMBL3624023 | 0.74 | AR (0.52) | ARCTSBMAPTALDH1A1LMNA | |
| SCHEMBL5240888 | 0.74 | CTSB (0.66) | ARCTSBGAAMAPTHTT | |
| SCHEMBL4245020 | 0.73 | AR (0.60) | ARCTSBGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | disclosed |