Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | EBP | Q15125 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754749 | 1.00 | LSS (0.55) | LSSKCNH2NR1I2DRD2ADRA2C | |
| SCHEMBL9779266 | 0.89 | NR1I2 (0.60) | LSSKCNH2NR1I2DRD2ADRA2C | |
| SCHEMBL5752211 | 0.82 | KCNH2 (0.62) | LSSKCNH2BCHEACHE | |
| SCHEMBL5752214 | 0.82 | KCNH2 (0.62) | LSSKCNH2BCHEACHE | |
| SCHEMBL28917084 | 0.81 | G6PC1 (0.42) | LSSOPRK1MEN1KMT2AMAOA | |
| SCHEMBL5426277 | 0.79 | HTR2A (0.60) | KCNH2NR1I2DRD2ADRA2CCNR1 | |
| SCHEMBL5426275 | 0.79 | HTR2A (0.60) | KCNH2NR1I2DRD2ADRA2CCNR1 | |
| SCHEMBL6711976 | 0.78 | NAMPT (0.53) | LSSKCNH2NR1I2DRD2ADRA2C | |
| SCHEMBL6711978 | 0.78 | NAMPT (0.53) | LSSKCNH2NR1I2DRD2ADRA2C | |
| SCHEMBL19249860 | 0.77 | KCNH2 (0.70) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1387841-B1 | NOVEL AZOLE OR TRIAZOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE THEREOF AS FUNGICIDES | AVENTIS PHARMA SA (FR) | 2006-03-08 | — | — | EP | disclosed |
| US-6960600-B2 | Azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments | AVENTIS PHARMA S.A. (FR) | 2005-11-01 | — | — | US | disclosed |
| US-6946460-B2 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides | AVENTIS PHARMA S.A. (FR) | 2005-09-20 | — | — | US | disclosed |
| EP-1387837-B1 | NOVEL AZOLE OR TRIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS ANTIFUNGAL MEDICINES | AVENTIS PHARMA SA (FR) | 2005-07-27 | — | — | EP | disclosed |
| US-20050043540-A1 | Novel azole or triazole derivatives, method for preparing same and use thereof as fungicides | AVENTIS PHARMA S. A, (FR) | 2005-02-24 | — | — | US | disclosed |
| US-20040192922-A1 | Novel azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments | AVENTIS PHARMA S.A. (FR) | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043540-A1 | Novel azole or triazole derivatives, method for preparing same and use thereof as fungicides | CYP1A2, CYP1B1, CYP21A2 | LSS 150/4885KCNH2 1556/4885NR1I2 50/4885 |
| US-20040192922-A1 | Novel azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments | ERG28, CYP51A1, CYP3A7 | LSS 37/4885KCNH2 3337/4885NR1I2 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.