SCHEMBL6712376

SCHEMBL6712376

Cc1cccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccccc2Cl)c1NC(=O)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.45
CARM1 Q86X55 2/20 0.44
KLKB1 P03952 3/20 0.44
F10 P00742 9/20 0.43
RXRA P19793 2/20 0.42
NR1H2 P55055 2/20 0.42
NR1H3 Q13133 2/20 0.42
NPY5R Q15761 1/20 0.42
F2 P00734 3/20 0.42
PROC P04070 1/20 0.41
PRSS1 P07477 1/20 0.41
CXCL8 P10145 1/20 0.40
TRPV1 Q8NER1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6713256 0.87 DHODH (0.41) MAPK14CARM1KLKB1F10NPY5R
SCHEMBL6783789 0.85 KLKB1 (0.48) MAPK14CARM1KLKB1F10RXRA
SCHEMBL6677548 0.83 KDM4E (0.40) MAPK14CARM1KLKB1F10TRPV1
SCHEMBL4769625 0.83 CARM1 (0.42) MAPK14CARM1KLKB1F10RXRA
SCHEMBL6689281 0.82 KLKB1 (0.44) MAPK14KLKB1F10RXRANR1H2
SCHEMBL6713134 0.81 MAPK14 (0.53) MAPK14RXRANR1H2NR1H3NPY5R
SCHEMBL12361685 0.80 F10 (0.49) CARM1KLKB1F10F2PROC
SCHEMBL2261049 0.80 KLKB1 (0.45) CARM1KLKB1F10F2PROC
SCHEMBL2260222 0.79 NPY5R (0.53) KLKB1F10NPY5RF2PROC
SCHEMBL2259914 0.79 NPY5R (0.52) KLKB1F10RXRANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040235959-A1 Insecticidal diamides E. I. DU PONT DE NEMOURS AND COMPANY 2004-11-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040235959-A1 Insecticidal diamides DDT, NRDC, NOXO1 MAPK14 2425/4885CARM1 757/4885KLKB1 4524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.