Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6712688 | 0.85 | ESR1 (0.38) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL6710249 | 0.85 | ESR1 (0.42) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL6713956 | 0.85 | ESR1 (0.42) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL6714537 | 0.85 | ESR1 (0.42) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL6712687 | 0.85 | ESR1 (0.38) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL7559972 | 0.85 | ESR1 (0.37) | ESR1ESR2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2474476 | 0.84 | ESR1 (0.37) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL2474474 | 0.84 | ESR1 (0.37) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL6712745 | 0.84 | ESR1 (0.37) | ESR1ESR2HSP90AA1PDCD1LG2CD274 | |
| SCHEMBL6709980 | 0.83 | ESR1 (0.38) | ESR1ESR2HSP90AA1PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229910-A1 | Therapeutic compounds | N.V. ORGANON (NL) | 2004-11-18 | — | — | US | disclosed |
| EP-0898566-B1 | SUBSTITUTED BENZYLAMINES AND THEIR USE FOR THE TREATMENT OF DEPRESSION | AKZO NOBEL NV (NL) | 2002-11-06 | — | — | EP | disclosed |
| US-20020037885-A1 | Therapeutic compounds | DIJCKS FREDERICUS ANTONIUS (NL) | 2002-03-28 | — | — | US | disclosed |
| US-6313139-B1 | ADMINISTERING BENZYLAMINE DERIVATIVE FOR THERAPY OF PSYCHIATRIC DISORDER IN MAMMALS | AKZO NOBEL N. V. (NL) | 2001-11-06 | — | — | US | disclosed |
| US-6080773-A | USEFUL FOR TREATMENT OF DEPRESSION, ANXIETY OR PSYCHOSIS | AKZO NOBEL, N.V. (NL) | 2000-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229910-A1 | Therapeutic compounds | BDNF, PNMT, SLC18A2 | ESR1 2865/4885ESR2 1589/4885HSP90AA1 2140/4885 |
| US-20020037885-A1 | Therapeutic compounds | BDNF, PNMT, SLC18A2 | ESR1 2865/4885ESR2 1589/4885HSP90AA1 2140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.