Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | RAD52 | P43351 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466719 | 0.90 | KDM1A (0.53) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL6712768 | 0.84 | KMT2A (0.62) | KDM1AKMT2ARAD52POLBMEN1 | |
| SCHEMBL29531575 | 0.84 | KMT2A (0.62) | KDM1AKMT2ARAD52POLBMEN1 | |
| SCHEMBL12466637 | 0.84 | HDAC3 (0.48) | KDM1AKMT2ARAD52POLBMEN1 | |
| SCHEMBL6714254 | 0.82 | ATM (0.48) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL6714258 | 0.82 | ATM (0.48) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL15065069 | 0.82 | ATM (0.48) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL6711317 | 0.81 | L3MBTL1 (0.60) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL902770 | 0.80 | KDM1A (1.00) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL6719016 | 0.79 | KDM1A (0.46) | KDM1AKMT2ARAD52POLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952033-B2 | 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-02-10 | — | — | US | disclosed |
| US-8952033-B2 | 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-02-10 | — | — | US | disclosed |
| US-8952033-B2 | 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-02-10 | — | — | US | disclosed |
| US-20130172336-A1 | 4-ANILINOFURO[2,3-B]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2013-07-04 | — | — | US | disclosed |
| US-20130172336-A1 | 4-ANILINOFURO[2,3-B]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2013-07-04 | — | — | US | disclosed |
| WO-2012102965-A1 | 4-ANILINOFURO[2,3-b]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (CN) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012102965-A1 | 4-ANILINOFURO[2,3-b]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (CN) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012102965-A1 | 4-ANILINOFURO[2,3-b]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (CN) | 2012-08-02 | — | — | WO | disclosed |
| US-6750223-B2 | TO INHIBIT THE GROWTH OF A VARIETY OF TUMOR/CANCER CELLS, ESPECIALLY LEUKEMIA, COLON, MELANOMA, AND BREAST CANCER CELLS | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2004-06-15 | — | — | US | disclosed |
| US-20040072856-A1 | 4-ANILINO[2,3-b]QUINOLINE DERIVATIVES,THEIR PREPARATION PROCECC ANDPHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072856-A1 | 4-ANILINO[2,3-b]QUINOLINE DERIVATIVES,THEIR PREPARATION PROCECC ANDPHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | ADRA2C, CYP4B1, NQO2 | KDM1A 2546/4885KMT2A 2082/4885RAD52 1524/4885 |
| US-20130172336-A1 | 4-ANILINOFURO[2,3-B]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | NQO2, UGT2B7, UGT2B17 | KDM1A 2165/4885KMT2A 1794/4885RAD52 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.