⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750946 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL4270369 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL4751315 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL8641626 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL11702771 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL9805946 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL8645590 | 0.97 | — | — | |
| SCHEMBL8640654 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL2228165 | 0.97 | OPRM1 (0.55) | — | |
| SCHEMBL4751263 | 0.97 | OPRM1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103923092-A | Tetrandrine derivatives and preparation method and application thereof in preparation of antitumor medicine | UNIV SHANDONG NORMAL | 2014-07-16 | — | — | CN | claimed |
| US-5773658-A | REACTING AN ALDEHYDE WITH A PRIMARY AMINE TO FORM SCHIFF BASE; THEN WITH METHYLAMINE AND HYDROGEN IN PRESENCE OF A HYDROGENATION CATALYST | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | claimed |
| EP-0484790-B1 | Process for the preparation of N-methyl-alkylamines | HOECHST AG (DE) | 1994-09-14 | — | — | EP | claimed |
| US-11760897-B2 | Coating compositions including a sag control agent and wax | AXALTA COATING SYSTEMS IP CO., LLC (US) | 2023-09-19 | — | — | US | disclosed |
| EP-4004128-A1 | COATING COMPOSITIONS INCLUDING A SAG CONTROL AGENT AND WAX | Axalta Coating Systems GmbH (CH) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021022071-A1 | COATING COMPOSITIONS INCLUDING A SAG CONTROL AGENT AND WAX | AXALTA COATING SYSTEMS IP CO., LLC (US) | 2021-02-04 | — | — | WO | disclosed |
| US-20210032491-A1 | COATING COMPOSITIONS INCLUDING A SAG CONTROL AGENT AND WAX | AXALTA COATING SYSTEMS IP CO., LLC (US) | 2021-02-04 | — | — | US | disclosed |
| US-9605164-B2 | Low solids coating compositions having polyurea rheology control agents, methods for making such coating compositions, and systems for making such coating compositions | AXALTA COATING SYSTEMS IP CO., LLC (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150105511-A1 | LOW SOLIDS COATING COMPOSITIONS HAVING POLYUREA RHEOLOGY CONTROL AGENTS, METHODS FOR MAKING SUCH COATING COMPOSITIONS, AND SYSTEMS FOR MAKING SUCH COATING COMPOSITIONS | BARCLAYS BANK PLC, AS COLLATERAL AGENT | 2015-04-16 | — | — | US | disclosed |
| CN-103923092-A | Tetrandrine derivatives and preparation method and application thereof in preparation of antitumor medicine | UNIV SHANDONG NORMAL | 2014-07-16 | — | — | CN | disclosed |
| CN-103910739-A | Bisbenzylisoquinoline glycine betaines as well as preparation method and application thereof in preparing anti-tumor medicines | UNIV SHANDONG NORMAL | 2014-07-09 | — | — | CN | disclosed |
| US-20040214157-A1 | CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME | BURTON SIMON C (NZ) | 2004-10-28 | — | — | US | disclosed |
| US-5773658-A | REACTING AN ALDEHYDE WITH A PRIMARY AMINE TO FORM SCHIFF BASE; THEN WITH METHYLAMINE AND HYDROGEN IN PRESENCE OF A HYDROGENATION CATALYST | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| EP-0215238-B1 | PROCESS FOR PURIFYING THIOCARBAMYLSULFENAMIDES | The B.F. GOODRICH Company (US) | 1989-10-11 | — | — | EP | disclosed |
| EP-0215238-A1 | Process for purifying thiocarbamylsulfenamides | The B.F. GOODRICH Company (US) | 1987-03-25 | — | — | EP | disclosed |
| US-4639517-A | Process for stabilizing thiocarbamylsulfenamides | THE B F GOODRICH COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| US-4632986-A | Process for purifying thiocarbamylsulfenamides | THE BFGOODRICH COMPANY (US) | 1986-12-30 | — | — | US | disclosed |
| US-4084053-A | YELLOW AND ORANGE DYES, PYRIMIDINO(4',5':5,6)-1,2,4-TRIAZINO(4,3-BETA)INDAZOLES | CIBA-GEIGY CORPORATION (US) | 1978-04-11 | — | — | US | disclosed |
| US-3985743-A | FROM AN AMINE AND A MONOHALOAMINE WTIH CARBON DISULFIDE IN A BASE | THE B. F. GOODRICH COMPANY (US) | 1976-10-12 | — | — | US | disclosed |