Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HTR1D | P28221 | 5/20 | 0.53 |
| ▸ | HTR1B | P28222 | 5/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RBP4 | P02753 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6717901 | 0.92 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6720302 | 0.92 | HTR1A (0.55) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6714739 | 0.92 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6714953 | 0.92 | CA12 (0.53) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6717572 | 0.90 | MAPT (0.55) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6718482 | 0.90 | SMN1; SMN2 (0.55) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6714762 | 0.89 | MAPT (0.68) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6717558 | 0.88 | MAPT (0.58) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6724729 | 0.88 | HTR1A (0.52) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL6714894 | 0.87 | HTR1A (0.49) | HTR1AHTR1DHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | claimed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |