Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6717901 | 0.89 | HTR1A (0.62) | MAPTLMNASMN1; SMN2HSD17B10GAA | |
| SCHEMBL6714953 | 0.89 | CA12 (0.53) | MAPTSMN1; SMN2ALDH1A1MAPK1HTR1A | |
| SCHEMBL6716503 | 0.89 | HTR1A (0.53) | MAPTLMNASMN1; SMN2GAAHTT | |
| SCHEMBL6714759 | 0.87 | MAPT (0.70) | MAPTLMNASMN1; SMN2HSD17B10GAA | |
| SCHEMBL6718482 | 0.87 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2ALDH1A1HTR1AHTR1D | |
| SCHEMBL6717558 | 0.87 | MAPT (0.58) | MAPTLMNASMN1; SMN2HSD17B10GAA | |
| SCHEMBL6718699 | 0.86 | HTR1A (0.49) | MAPTLMNASMN1; SMN2USP2TP53 | |
| SCHEMBL6724729 | 0.85 | HTR1A (0.52) | MAPTSMN1; SMN2ALDH1A1MAPK1HTR1A | |
| SCHEMBL6716667 | 0.84 | HTR1A (0.47) | MAPTLMNATSHRALDH1A1MAPK1 | |
| SCHEMBL6720386 | 0.84 | KDM4E (0.59) | MAPTLMNASMN1; SMN2HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | claimed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |