Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CMA1 | P23946 | 3/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.52 |
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR1D | P28221 | 5/20 | 0.50 |
| ▸ | HTR1B | P28222 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724805 | 0.95 | NPSR1 (0.56) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6725600 | 0.94 | NPSR1 (0.59) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6720525 | 0.92 | PFKFB3 (0.59) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6720472 | 0.89 | NPSR1 (0.56) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6720605 | 0.87 | NPSR1 (0.54) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6714975 | 0.86 | PFKFB4 (0.55) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6720554 | 0.85 | PFKFB3 (0.58) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6716565 | 0.84 | PFKFB3 (0.59) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL12204617 | 0.80 | NPSR1 (0.90) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL733290 | 0.79 | NPSR1 (0.65) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818651-B2 | ANTIINFLAMMATORY, ANTIASTHMATIC, SKIN, AND AUTOIMMUNE DISORDERS; CROHN*S DISEASE, ULCERATIVE COLITIS, CONJUCTIVITIS, MULTIPLE SCLEROSIS, AND RHEUMATOID ARTHRITIS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ALTANA PHARMA AG (DE) | 2004-11-16 | — | — | US | disclosed |
| US-20040044212-A1 | (Dihydro) Isoquinoline derivatives as phosphodiesterase inhibitors | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | US | disclosed |
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044212-A1 | (Dihydro) Isoquinoline derivatives as phosphodiesterase inhibitors | PDE7B, PDE3B, PDE3A | NPSR1 3797/4885L3MBTL1 4650/4885CMA1 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.