Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326881 | 0.88 | CTSL (0.51) | CYP17A1ALDH1A1PTGDR2MMP1MMP2 | |
| SCHEMBL1854425 | 0.87 | NPSR1 (0.46) | MTORCYP17A1PPARGPPARAALDH1A1 | |
| SCHEMBL1853151 | 0.83 | CYP17A1 (0.54) | MTORCYP17A1PPARGPPARAMAPT | |
| SCHEMBL1854428 | 0.82 | MTOR (0.42) | MTORCYP17A1P2RY14PPARGPPARA | |
| SCHEMBL1138925 | 0.82 | EPHX2 (0.59) | CYP17A1P2RY14ALDH1A1MAPTLMNA | |
| SCHEMBL1854866 | 0.76 | KCNQ3 (0.54) | MTORALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1851161 | 0.76 | CTSL (0.49) | CYP17A1PPARGPPARAALDH1A1PTGDR2 | |
| SCHEMBL30929531 | 0.76 | EPHX2 (0.51) | CYP17A1P2RY14MAPTLMNAHTT | |
| SCHEMBL22930812 | 0.76 | CYP17A1 (0.57) | CYP17A1PPARGPPARAPTGDR2MMP1 | |
| SCHEMBL1854194 | 0.75 | PLK1 (0.58) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |