Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.64 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.52 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.52 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.52 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724478 | 0.83 | KMO (0.74) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL4772196 | 0.80 | KMO (0.65) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL303084 | 0.78 | KMO (0.77) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL65857 | 0.78 | KMO (1.00) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL30634127 | 0.78 | KMO (1.00) | KMOPLOD2PLOD3PLOD1PRKDC | |
| Hydrochloric Acid SCHEMBL14742166 | 0.77 | KMO (0.74) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL4251811 | 0.77 | KMO (0.74) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL828075 | 0.77 | KMO (0.68) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL22811005 | 0.77 | KMO (0.68) | KMOPLOD2PLOD3PLOD1PRKDC | |
| SCHEMBL22209343 | 0.77 | KMO (0.68) | KMOPLOD2PLOD3PLOD1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606050-A2 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS SELECTIVE JAK INHIBITORS | Cellzome Limited (GB) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022681-A2 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS SELECTIVE JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-02-23 | — | — | WO | disclosed |