Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851806 | 0.89 | FFAR1 (0.50) | FFAR1FFAR4CYP1A2CYP2C9MMP2 | |
| SCHEMBL6023224 | 0.79 | CYSLTR2 (0.38) | FFAR1FFAR4CNR2CYP1A2CYP3A4 | |
| SCHEMBL4966603 | 0.79 | PLK1 (0.43) | PTGESFAAHFFAR1FFAR4 | |
| SCHEMBL1853461 | 0.77 | PTGES (0.43) | PTGESFFAR1FFAR4AKR1C3MMP2 | |
| SCHEMBL4978882 | 0.77 | PLK1 (0.47) | FAAHCYP1A2CYP2C9SMN1; SMN2PPARA | |
| SCHEMBL4981880 | 0.76 | ACACB (0.42) | PTGESFFAR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1853105 | 0.76 | PTGES (0.52) | PTGESFFAR1FFAR4AKR1C3MMP2 | |
| SCHEMBL1852713 | 0.75 | ACACB (0.51) | FAAH | |
| SCHEMBL10801717 | 0.75 | FFAR1 (0.51) | PTGESFFAR1FFAR4MMP2MMP12 | |
| SCHEMBL1855040 | 0.74 | SCN8A (0.40) | PTGESFAAHFFAR1FFAR4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | claimed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | claimed |